Inhibition of Topo I stabilizes telomere damage
نویسندگان
چکیده
Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute ,Rome, Italy; Anatomic Pathology Institute, Tor Vergata University, Rome; Department of Chemistry, La Sapienza University, Rome; School of Pharmacy, the University of Nottingham, Nottingham, UK; Laboratory of Biology and Pathology of Genomes of University of Nice Sophia-Antipolis, CNRS UMR6267/INSERM U998, Faculty of Medicine and Department of Medical Genetics, CHU of Nice, France; Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy; SigmaTau, Pomezia, Italy.
منابع مشابه
Inhibition of Topo I stabilizes telomere damage 1 DNA damage persistence as determinant of tumor sensitivity to the combination of Topo I inhibitors and telomere - targeting agents
Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute ,Rome, Italy; Anatomic Pathology Institute, Tor Vergata University, Rome; Department of Chemistry, La Sapienza University, Rome; School of Pharmacy, the University of Nottingham, Nottingham, UK; Laboratory of Biology and Pathology of Genomes of University of Nice Sophia-Antipolis, CNRS UMR6267/INSERM U998, Faculty of Medicine a...
متن کاملCancer Therapy: Preclinical DNA Damage Persistence as Determinant of Tumor Sensitivity to the Combination of Topo I Inhibitors and Telomere-Targeting Agents
Purpose: We previously reported that the G-quadruplex (G4) ligand RHPS4 potentiates the antitumor activity of camptothecins both in vitro and in tumor xenografts. The present study aims at investigating the mechanisms involved in this specific drug interaction. Experimental Design: Combination index test was used to evaluate the interaction between G4 ligands and standard or novel Topo I inhibi...
متن کاملDNA damage persistence as determinant of tumor sensitivity to the combination of Topo I inhibitors and telomere-targeting agents.
PURPOSE We previously reported that the G-quadruplex (G4) ligand RHPS4 potentiates the antitumor activity of camptothecins both in vitro and in tumor xenografts. The present study aims at investigating the mechanisms involved in this specific drug interaction. EXPERIMENTAL DESIGN Combination index test was used to evaluate the interaction between G4 ligands and standard or novel Topo I inhibi...
متن کاملThe G-Quadruplex Ligand Telomestatin Impairs Binding of Topoisomerase IIIα to G-Quadruplex-Forming Oligonucleotides and Uncaps Telomeres in ALT Cells
In Alternative Lengthening of Telomeres (ALT) cell lines, specific nuclear bodies called APBs (ALT-associated PML bodies) concentrate telomeric DNA, shelterin components and recombination factors associated with telomere recombination. Topoisomerase IIIalpha (Topo III) is an essential telomeric-associated factor in ALT cells. We show here that the binding of Topo III to telomeric G-overhang is ...
متن کاملApoptosis as a Determinant of Tumor Sensitivity to Topotecan in Human Ovarian Tumors: Predinical in Vitro/in Vivo
In their paper on apoptosis and topotecan sensitivity, Casemi et a!. (1) highlight an important aspect of Topo I’ inhibitor effect on the cancer cell, i.e., its ability to undergo apoptosis following drug-target interaction. The antiproliferative activity of the Topo I inhibitors seems to be different from their apoptotic induction potential. Indeed, this difference may have significant bearing...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011